Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway

Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease

Skeletal muscle atrophy and impaired muscle function are associated with lower health-related quality of life, and greater disability and mortality risk in those with chronic kidney disease (CKD). However, the pathogenesis of skeletal dysfunction in CKD is unknown. We used a slow progressing, naturally occurring, CKD rat model (Cy/+ rat) with hormonal abnormalities consistent with clinical pres...

Heat stress causes dysfunctional autophagy in oxidative skeletal muscle

We have previously established that 24 h of environmental hyperthermia causes oxidative stress and have implicated mitochondria as likely contributors to this process. Given this, we hypothesized that heat stress would lead to increased autophagy/mitophagy and a reduction in mitochondrial content. To address this hypothesis pigs were housed in thermoneutral (TN; 20°C) or heat stress (35°C) cond...

Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease

BACKGROUND Accelerated muscle atrophy is associated with a three-fold increase in mortality in chronic kidney disease (CKD) patients. It is suggested that hyperphosphatemia might contribute to muscle wasting, but the underlying mechanisms remain unclear. Although evidence indicates that autophagy is involved in the maintenance of muscle homeostasis, it is not known if high phosphate levels can ...

OXIDATIVE STRESS AND MICROVASCULAR FUNCTION IN CHRONIC KIDNEY DISEASE by

Oxidative Stress in Chronic Kidney Disease

1Department of Nephrology, Odense University Hospital and Institute of Clinical Research, University of Southern Denmark, 5000 Odense C, Denmark 2Institute for Molecular Cardiovascular Research, RWTH Aachen University, University Hospital, 52074 Aachen, Germany 3Faculty of Chemistry, Department of Biology, National Autonomous University of Mexico (UNAM), 04510 Mexico City, Mexico 4Laboratory of...